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KMID : 0861020120270030107
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Korea Journal of Herbology
2012 Volume.27 No. 3 p.107 ~ p.112
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Effects of Tong Xin Lou (TXL) on levels of serum lipid in high fat diet-induced dyslipidemia in mice
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Ha Tae-Hoon
Kim Hyun-Yung
Kim Hyung-Woo
Cho Su-In
Kim Young-Kyoon
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Abstract
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Objectives: This study was designed to investigate the effects of Tong Xin Lou (TXL) on lipid accumulation in
liver tissue in Hypercholesterolemic mice. TXL is new drug, which is one of Cardiotonic Pills. TXL is used for
activating the blood flow in the restoration stage of cerebral infarction, and for alleviation of angina pectoris
including the symptoms as chest oppressed and stabbing pain.
Methods: Hyperlipidemia was induced by providing high fat diet for 6 weeks. Normal group was provided with
normal rodent diet. TXL was administered orally in the concentration of 10 ㎎/day for 2 weeks (TXL group).
D/W was administered orally in CTL group for 2 weeks. We observed histopathological changes in liver and
heart tissues, and also investigated the effect on body weights, and levels of total cholesterol, HDL-cholesterol,
LDL-cholesterol and triglyceride in serum.
Results: In this study, TXL did not affects weight gain in hypercholesterolemic mice. TXL group showed
downward tendency of lipid accumulation compared with CTL group. In addition, oral administration of TXL
lowered levels of total cholesterol (P < 0.05) and triglyceride (P < 0.05), which were elevated by induction of
hypercholesterolemia.
Conclusion: These results suggest that TXL can prevent lipid accumulation in liver tissue through regulation of
dyslipidemia.
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KEYWORD
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Tong Xin Lou, Cardiotonic Pills, Hyperlididemia, dyslipidemia
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